Article
KRAS mutations in patients with colorectal cancer as detected by high-resolution melting analysis and direct sequencing.
Anticancer research - 1 May 2013
Akiyoshi Kohei, Yamada Yasuhide, Honma Yoshitaka, Iwasa Satoru, Kato Ken, Hamaguchi Tetsuya, Shimada Yasuhiro, Taniguchi Hirokazu, Furuta Koh
Abstract excerpt
BACKGROUND: Direct sequencing (DS) has often been used for detection of v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (KRAS) mutations. High-resolution melting analysis (HRMA) is another method to detect mutations by using a light scanner, and is more rapid, lower in cost, and more sensitive than DS. We confirmed correspondence between DS and HRMA for KRAS mutation detection in colorectal cancer (CRC)....
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