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Article

Detection of KRAS mutations in colorectal cancer by high-resolution melting analysis.

Journal of clinical pathology - 1 Oct 2009

Ma E S K, Wong C L P, Law F B F, Chan W-K, Siu D

Abstract excerpt

AIMS: Mutation of the KRAS gene predicts the clinical response to the monoclonal antibody cetuximab in patients with advanced colorectal cancer (CRC). This study aimed to perform KRAS mutation detection on formalin-fixed paraffin-embedded (FFPE) tumour tissue by two different methods for comparison. METHODS: The FFPE sample was microdissected to enrich for tumour cells. KRAS exon 2 mutations were performed on 100...

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Share to Antibodies, Monoclonal
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 19783717
DOI: 10.1136/jcp.2008.063677

Genes

KRAS

Variants

Provenance

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