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Article

High-resolution melting assay (HRMA) is a simple and sensitive stool-based DNA Test for the detection of mutations in colorectal neoplasms.

Clinical colorectal cancer - 1 Dec 2012

Li Bing-Sheng, Wang Xin-Ying, Xu An-Gao, Ma Feng-Li, Ma Qun-Ying, Li Zao, Liu Ji-Hong, Gan Ai-Hua, Yu Zhi-Jin, Zhang Xiao-Hui, Jiang Bo

Abstract excerpt

BACKGROUND: Stool-based DNA testing for colorectal cancer is becoming a favored alternative to existing DNA screening tests. However, current methods of analysis often become more complicated and costly with increased sensitivity. The high-resolution melting assay (HRMA) is a simple and rapid mutation scanning method with low cost and superb accuracy. In this study, we verified the accuracy of HRMA for screening...

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PMID: 22609129
DOI: 10.1016/j.clcc.2012.04.001

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KRAS

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