Article
MicroRNA variants as genetic determinants of bone mass.
Bone - 1 Mar 2016
Dole Neha S, Delany Anne M
Abstract excerpt
Single nucleotide polymorphisms (SNPs) are the most abundant genetic variants that contribute to the heritability of bone mass. MicroRNAs (miRNAs, miRs) are key post-transcriptional regulators that modulate the differentiation and function of skeletal cells by targeting multiple genes in the same or distinct signaling pathways. SNPs in miRNA genes and miRNA binding sites can alter miRNA abundance and mRNA...
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