Article
Enhanced C/EBP binding to G·T mismatches facilitates fixation of CpG mutations in cancer and adult stem cells.
Cell reports - 8 Jun 2021
Ershova Anna S, Eliseeva Irina A, Nikonov Oleg S, Fedorova Alla D, Vorontsov Ilya E, Papatsenko Dmitry, Kulakovskiy Ivan V
Abstract excerpt
Somatic mutations in regulatory sites of human stem cells affect cell identity or cause malignant transformation. By mining the human genome for co-occurrence of mutations and transcription factor binding sites, we show that C/EBP binding sites are strongly enriched with [C > T]G mutations in cancer and adult stem cells, which is of special interest because C/EBPs regulate cell fate and differentiation. In vitro...
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