Article
Translational enhancement of the poliovirus 5' noncoding region mediated by virus-encoded polypeptide 2A.
1 Nov 1992
Abstract excerpt
Genetic and biochemical studies have revealed that the 5' noncoding region of poliovirus mediates translation of the viral mRNA by an unusual mechanism involving entry of ribosomes in internal sequences of mRNA molecules. We have found that mRNAs bearing the 5' noncoding region of poliovirus were translated at an enhanced rate in poliovirus-infected mammalian cells at a time when translation of cellular mRNAs was...