Chromosome 9p21 and Cardiovascular Disease

Abstract excerpt

T he middle of 2007 saw what may, with time, turn out to be the single most important discovery in the genetics of cardiovascular diseases. ] The risk allele as currently defined, until causal variants are identified, is common (allele frequency of almost 50%) and associated with a 20% to 30% increased risk per copy. The effect of the 9p21 locus on CAD and MI risk is unaltered by adjustment for traditional...

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