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Article

Identification of single nucleotide polymorphisms in the p21 (CDKN1A) gene and correlations with longevity in the Italian population.

Aging - 1 May 2009

Gravina Silvia, Lescai Francesco, Hurteau Gregory, Brock Graham J, Saramaki Anna, Salvioli Stefano, Franceschi Claudio, Roninson Igor B

Abstract excerpt

Longevity in humans is determined by multiple environmental and genetic factors. We have investigated possible associations between longevity and Single Nucleotide Polymorphisms (SNPs) in the p21 (CDKN1A) gene, a stress-inducible senescence-associated cell cycle inhibitor, expression of which upregulates genes implicated in several age-related diseases. By sequencing the promoter and exons of p21 in genomic DNA...

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Share to Cyclin-Dependent Kinase Inhibitor p21
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 20126416
DOI: 10.18632/aging.100041
PMCID: PMC2814366

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