Article
The coronary artery disease-associated 9p21 variant and later life 20-year survival to cohort extinction.
Circulation. Cardiovascular genetics - 1 Oct 2011
Dutta Ambarish, Henley William, Lang Iain A, Murray Anna, Guralnik Jack, Wallace Robert B, Melzer David
Abstract excerpt
BACKGROUND: Common variation at chromosome 9p21 (marked by rs10757278 or rs1333049) is associated with coronary artery disease (CAD) and peripheral vascular disease. A decreasing effect at older age was suggested, and effects on long-term mortality are unclear. We estimated 9p21 associations with CAD and all-cause mortality in a CAD diagnosis-free older population. We also estimated classification gains on adding...
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