Article
Genome-wide association study of intracranial aneurysm identifies a new association on chromosome 7.
Stroke - 1 Nov 2014
Foroud Tatiana, Lai Dongbing, Koller Daniel, Van't Hof Femke, Kurki Mitja I, Anderson Craig S, Brown Robert D, Connolly Edward Sander, Eriksson Johan G, Flaherty Matthew, Fornage Myriam, von Und Zu Fraunberg Mikael, Gaál Emília I, Laakso Aki, Hernesniemi Juha, Huston John, Jääskeläinen Juha E, Kiemeney Lambertus A, Kivisaari Riku, Kleindorfer Dawn, Ko Nerissa, Lehto Hanna, Mackey Jason, Meissner Irene, Moomaw Charles J, Mosley Thomas H, Moskala Marek, Niemelä Mika, Palotie Aarno, Pera Joanna, Rinkel Gabriel, Ripke Stephan, Rouleau Guy, Ruigrok Ynte, Sauerbeck Laura, Słowik Agnieszka, Vermeulen Sita H, Woo Daniel, Worrall Bradford B, Broderick Joseph
Abstract excerpt
BACKGROUND AND PURPOSE: Common variants have been identified using genome-wide association studies which contribute to intracranial aneurysms (IA) susceptibility. However, it is clear that the variants identified to date do not account for the estimated genetic contribution to disease risk. METHODS: Initial analysis was performed in a discovery sample of 2617 IA cases and 2548 controls of white ancestry. Novel...
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