Article
Genome-wide association study of intracranial aneurysms confirms role of Anril and SOX17 in disease risk.
Stroke - 1 Nov 2012
Foroud Tatiana, Koller Daniel L, Lai Dongbing, Sauerbeck Laura, Anderson Craig, Ko Nerissa, Deka Ranjan, Mosley Thomas H, Fornage Myriam, Woo Daniel, Moomaw Charles J, Hornung Richard, Huston John, Meissner Irene, Bailey-Wilson Joan E, Langefeld Carl, Rouleau Guy, Connolly E Sander, Worrall Bradford B, Kleindorfer Dawn, Flaherty Matthew L, Martini Sharyl, Mackey Jason, De Los Rios La Rosa Felipe, Brown Robert D, Broderick Joseph P
Abstract excerpt
BACKGROUND: Genomewide association studies have identified novel genetic factors that contribute to intracranial aneurysm (IA) susceptibility. We sought to confirm previously reported loci, to identify novel risk factors, and to evaluate the contribution of these factors to familial and sporadic IA. METHOD: We utilized 2 complementary samples, one recruited on the basis of a dense family history of IA (discovery...
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