Article
Association of HLA-DR-DQ alleles, haplotypes, and diplotypes with type 1 diabetes in Saudis.
Diabetes/metabolism research and reviews - 1 Nov 2020
Eltayeb-Elsheikh Nezar, Khalil Eltahir, Mubasher Mohamed, AlJurayyan Abdullah, AlHarthi Hanan, Omer Waleed H, Elghazali Inas, Sherbeeni Suphia M, Alghofely Mohammed A, Ilonen Jorma, Elghazali Gehad
Abstract excerpt
AIMS: Type 1 diabetes (T1D) is an autoimmune disease that affects many children worldwide. Genetic factors and environmental triggers play crucial interacting roles in the aetiology. This study aimed to assess the contribution of HLA-DRB1-DQA1-DQB1 alleles, haplotypes, and genotypes to the risk of T1D among Saudis. METHODS: A total of 222 children with T1D and 342 controls were genotyped for HLA-DRB1, -DQA1, and...
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