Clinical features, epidemiology, autoantibody status, HLA haplotypes and genetic mechanisms of type 1 diabetes mellitus among children in Qatar.

doi:10.1038/s41598-021-98460-4

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Clinical features, epidemiology, autoantibody status, HLA haplotypes and genetic mechanisms of type 1 diabetes mellitus among children in Qatar.

Scientific reports - 23 Sept 2021

Haris Basma, Ahmed Ikhlak, Syed Najeeb, Almabrazi Hakeem, Saraswathi Saras, Al-Khawaga Sara, Saeed Amira, Mundekkadan Shihab, Mohammed Idris, Sharari Sanaa, Hawari Iman, Hamed Noor, Afyouni Houda, Abdel-Karim Tasneem, Mohammed Shayma, Khalifa Amel, Al-Maadheed Maryam, Zyoud Mahmoud, Shamekh Ahmed, Elawwa Ahmed, Karim Mohammed Y, Al-Khalaf Fawziya, Tatari-Calderone Zohreh, Petrovski Goran, Hussain Khalid

Abstract excerpt

To describe the clinical features, epidemiology, autoantibody status, HLA haplotypes and genetic mechanisms of type 1 diabetes mellitus (T1DM). Patients (0-18 years) with diabetes were recruited. Clinical data was collected, autoantibodies and c-peptide were measured. Whole Genome Sequencing was performed. Genomic data analysis was compared with the known genes linked with T1DM and HLA alleles were studied. 1096...

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PMID: 34556755
DOI: 10.1038/s41598-021-98460-4
PMCID: PMC8460652

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