Article
Structural and energetic determinants of adhesive binding specificity in type I cadherins.
Proceedings of the National Academy of Sciences of the United States of America - 7 Oct 2014
Vendome Jeremie, Felsovalyi Klara, Song Hang, Yang Zhongyu, Jin Xiangshu, Brasch Julia, Harrison Oliver J, Ahlsen Goran, Bahna Fabiana, Kaczynska Anna, Katsamba Phinikoula S, Edmond Darwin, Hubbell Wayne L, Shapiro Lawrence, Honig Barry
Abstract excerpt
Type I cadherin cell-adhesion proteins are similar in sequence and structure and yet are different enough to mediate highly specific cell-cell recognition phenomena. It has previously been shown that small differences in the homophilic and heterophilic binding affinities of different type I family members can account for the differential cell-sorting behavior. Here we use a combination of X-ray crystallography,...
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