Article
T-cadherin structures reveal a novel adhesive binding mechanism.
Nature structural & molecular biology - 1 Mar 2010
Ciatto Carlo, Bahna Fabiana, Zampieri Niccolò, VanSteenhouse Harper C, Katsamba Phini S, Ahlsen Goran, Harrison Oliver J, Brasch Julia, Jin Xiangshu, Posy Shoshana, Vendome Jeremie, Ranscht Barbara, Jessell Thomas M, Honig Barry, Shapiro Lawrence
Abstract excerpt
Vertebrate genomes encode 19 classical cadherins and about 100 nonclassical cadherins. Adhesion by classical cadherins depends on binding interactions in their N-terminal EC1 domains, which swap N-terminal beta-strands between partner molecules from apposing cells. However, strand-swapping sequence signatures are absent from nonclassical cadherins, raising the question of how these proteins function in adhesion....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.