Article
Two-step adhesive binding by classical cadherins.
Nature structural & molecular biology - 1 Mar 2010
Harrison Oliver J, Bahna Fabiana, Katsamba Phini S, Jin Xiangshu, Brasch Julia, Vendome Jeremie, Ahlsen Goran, Carroll Kilpatrick J, Price Stephen R, Honig Barry, Shapiro Lawrence
Abstract excerpt
Crystal structures of classical cadherins have revealed two dimeric configurations. In the first, N-terminal beta-strands of EC1 domains 'swap' between partner molecules. The second configuration (the 'X dimer'), also observed for T-cadherin, is mediated by residues near the EC1-EC2 calcium binding sites, and N-terminal beta-strands of partner EC1 domains, though held adjacent, do not swap. Here we show that...
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