Article
Identification and characterization of the X-dimer of human P-cadherin: implications for homophilic cell adhesion.
Biochemistry - 25 Mar 2014
Kudo Shota, Caaveiro Jose M M, Goda Shuichiro, Nagatoishi Satoru, Ishii Keisuke, Matsuura Tadashi, Sudou Yukio, Kodama Tatsuhiko, Hamakubo Takao, Tsumoto Kouhei
Abstract excerpt
Cell adhesion mediated by cadherins depends critically on the homophilic trans-dimerization of cadherin monomers from apposing cells, generating the so-called strand-swap dimer (ss-dimer). Recent evidence indicates that the ss-dimer is preceded by an intermediate species known as the X-dimer. Until now, the stabilized form of the X-dimer had only been observed in E-cadherin among the classical type I cadherins....
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