Article
Characterizing interactions in E-cadherin assemblages.
Biophysical journal - 8 Aug 2023
Shome Sayane, Jia Kejue, Sivasankar Sanjeevi, Jernigan Robert L
Abstract excerpt
Cadherin intermolecular interactions are critical for cell-cell adhesion and play essential roles in tissue formation and the maintenance of tissue structures. In this study, we focus on E-cadherin, a classical cadherin that connects epithelial cells, to understand how they interact in cis and trans conformations when attached to the same cell or opposing cells. We employ coevolutionary sequence analysis and...
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