Article
The renal urate transporter SLC17A1 locus: confirmation of association with gout.
Arthritis research & therapy - 27 Apr 2012
Hollis-Moffatt Jade E, Phipps-Green Amanda J, Chapman Brett, Jones Gregory T, van Rij Andre, Gow Peter J, Harrison Andrew A, Highton John, Jones Peter B, Montgomery Grant W, Stamp Lisa K, Dalbeth Nicola, Merriman Tony R
Abstract excerpt
INTRODUCTION: Two major gout-causing genes have been identified, the urate transport genes SLC2A9 and ABCG2. Variation within the SLC17A1 locus, which encodes sodium-dependent phosphate transporter 1, a renal transporter of uric acid, has also been associated with serum urate concentration. However, evidence for association with gout is equivocal. We investigated the association of the SLC17A1 locus with gout in...
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