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Article

The aspartic acid of Fyn at 390 is critical for neuronal migration during corticogenesis.

Experimental cell research - 1 Nov 2014

An Lei, Song Lingzhen, Zhang Wei, Lu Xi, Chen Shulin, Zhao Shanting

Abstract excerpt

The mammalian cerebral cortex develops through the coordinated migration of postmitotic neurons. Fyn, a member of the Src tyrosine kinase family (SFKs), is involved in the neuronal migration and the absence of Fyn leads to abnormal migration. However, the molecular mechanism whereby Fyn acts on migrating neurons has remained unclear. Here, we employed two Fyn mutants (Fyn259T and FynD390A) to investigate the...

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Identifiers

PMID: 25251774
DOI: 10.1016/j.yexcr.2014.09.012

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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