Article
Absence of Fyn and Src causes a reeler-like phenotype.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 14 Sept 2005
Kuo Gloria, Arnaud Lionel, Kronstad-O'Brien Priscilla, Cooper Jonathan A
Abstract excerpt
Nonreceptor protein tyrosine kinases of the Src family regulate the survival, proliferation, differentiation, and motility of many cell types, but their roles in brain development are unclear. Biochemical and in vitro experiments implicate Src and Fyn in the Reelin-dependent tyrosine phosphorylation of Dab1, which controls the positioning of radially migrating neurons in many brain regions. However, genetic...
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