Article
Human ATP-binding cassette G1 controls macrophage lipoprotein lipase bioavailability and promotes foam cell formation.
Arteriosclerosis, thrombosis, and vascular biology - 1 Sept 2012
Olivier Maryline, Tanck Michael W, Out Ruud, Villard Elise F, Lammers Bart, Bouchareychas Laura, Frisdal Eric, Superville Alexandre, Van Berkel Theo, Kastelein John J, Eck Miranda Van, Jukema J Wouter, Chapman M John, Dallinga-Thie Geesje M, Guerin Maryse, Le Goff Wilfried
Abstract excerpt
OBJECTIVE: The physiological function of the ATP-binding cassette G1 (ABCG1) transporter in humans is not yet elucidated, as no genetic disease caused by ABCG1 mutations has been documented. The goal of our study was, therefore, to investigate the potential role(s) of ABCG1 in lipid metabolism in humans. METHODS AND RESULTS: Here we report that among the 104 polymorphisms present in the ABCG1 gene, the analysis...
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