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Article

Targeted Deletion of Adipocyte Abca1 (ATP-Binding Cassette Transporter A1) Impairs Diet-Induced Obesity.

Arteriosclerosis, thrombosis, and vascular biology - 1 Apr 2018

Cuffe Helen, Liu Mingxia, Key Chia-Chi C, Boudyguina Elena, Sawyer Janet K, Weckerle Allison, Bashore Alexander, Fried Susan K, Chung Soonkyu, Parks John S

Abstract excerpt

OBJECTIVE: Adipose tissue cholesterol increases with adipocyte triglyceride content and size during development of obesity. However, how adipocyte cholesterol affects adipocyte function is poorly understood. The aim of this study was to evaluate the role of the cellular cholesterol exporter, Abca1 (ATP-binding cassette transporter A1), on adipose tissue function during diet-induced obesity. APPROACH AND RESULTS:...

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Share to 3T3-L1 Cells
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29348118
DOI: 10.1161/ATVBAHA.117.309880
PMCID: PMC5864538

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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