Article
Activation of diverse signalling pathways by oncogenic PIK3CA mutations.
Nature communications - 23 Sept 2014
Wu Xinyan, Renuse Santosh, Sahasrabuddhe Nandini A, Zahari Muhammad Saddiq, Chaerkady Raghothama, Kim Min-Sik, Nirujogi Raja S, Mohseni Morassa, Kumar Praveen, Raju Rajesh, Zhong Jun, Yang Jian, Neiswinger Johnathan, Jeong Jun-Seop, Newman Robert, Powers Maureen A, Somani Babu Lal, Gabrielson Edward, Sukumar Saraswati, Stearns Vered, Qian Jiang, Zhu Heng, Vogelstein Bert, Park Ben Ho, Pandey Akhilesh
Abstract excerpt
The PIK3CA gene is frequently mutated in human cancers. Here we carry out a SILAC-based quantitative phosphoproteomic analysis using isogenic knockin cell lines containing 'driver' oncogenic mutations of PIK3CA to dissect the signalling mechanisms responsible for oncogenic phenotypes induced by mutant PIK3CA. From 8,075 unique phosphopeptides identified, we observe that aberrant activation of PI3K pathway leads...
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