Article
Naturally occurring neomorphic PIK3R1 mutations activate the MAPK pathway, dictating therapeutic response to MAPK pathway inhibitors.
Cancer cell - 13 Oct 2014
Cheung Lydia W T, Yu Shuangxing, Zhang Dong, Li Jie, Ng Patrick K S, Panupinthu Nattapon, Mitra Shreya, Ju Zhenlin, Yu Qinghua, Liang Han, Hawke David H, Lu Yiling, Broaddus Russell R, Mills Gordon B
Abstract excerpt
PIK3R1 (p85α regulatory subunit of PI3K) is frequently mutated across cancer lineages. Herein, we demonstrate that the most common recurrent PIK3R1 mutation PIK3R1(R348∗) and a nearby mutation PIK3R1(L370fs), in contrast to wild-type and mutations in other regions of PIK3R1, confers an unexpected...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.