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Article

Defective dynamic properties of human cardiac troponin mutations.

Bioscience, biotechnology, and biochemistry - 1 Jan 2010

Lassalle Michael W

Abstract excerpt

Mutations in Troponin I (TnI) and Troponin T (TnT) are closely linked to familial hypertrophic cardiomyopathy (FHC) and hypertrophic cardiomyopathy (HCM), but the underlying molecular mechanism is not yet well understood. There might be a close link between the defective dynamic properties and the functional aberrations of hcTroponin. To prove this hypothesis, we undertook detailed NMR relaxation measurements of...

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Identifiers

PMID: 20057144
DOI: 10.1271/bbb.90586

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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