Article

Glioma Formation in Neurofibromatosis 1 Reflects Preferential Activation of K-RAS in Astrocytes

2005-01-01

Abstract excerpt

Abstract Children with the tumor predisposition syndrome, neurofibromatosis 1 (NF1), develop optic pathway gliomas. The NF1 gene product, neurofibromin, functions as a negative regulator of RAS, such that NF1 inactivation results in RAS hyperactivation. Recent studies have highlighted the divergent biological and biochemical properties of the various RAS isoforms, which prompted us to examine the consequence of Nf...

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Literature Corpus work: 18d5c58b-5808-5246-b0bc-eac05f3abd87
DOI: 10.1158/0008-5472.236.65.1

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