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Article

Brain-derived neurotrophic factor/FK506-binding protein 5 genotype by childhood trauma interactions do not impact on hippocampal volume and cognitive performance.

PloS one - 1 Jan 2014

Hernaus Dennis, van Winkel Ruud, Gronenschild Ed, Habets Petra, Kenis Gunter, Marcelis Machteld, van Os Jim, Myin-Germeys Inez, Collip Dina

Abstract excerpt

In the development of psychotic symptoms, environmental and genetic factors may both play a role. The reported association between childhood trauma and psychotic symptoms could therefore be moderated by single nucleotide polymorphisms (SNPs) associated with the stress response, such as FK506-binding protein 5 (FKBP5) and brain-derived neurotrophic factor (BDNF). Recent studies investigating childhood trauma by...

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Identifiers

PMID: 24658422
DOI: 10.1371/journal.pone.0092722
PMCID: PMC3962453

Genes

BDNF
FKBP5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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