Article
Failure of ductus arteriosus closure and remodeling in neonatal mice deficient in cyclooxygenase-1 and cyclooxygenase-2.
Proceedings of the National Academy of Sciences of the United States of America - 30 Jan 2001
Loftin C D, Trivedi D B, Tiano H F, Clark J A, Lee C A, Epstein J A, Morham S G, Breyer M D, Nguyen M, Hawkins B M, Goulet J L, Smithies O, Koller B H, Langenbach R
Abstract excerpt
The transition to pulmonary respiration following birth requires rapid alterations in the structure of the mammalian cardiovascular system. One dramatic change that occurs is the closure and remodeling of the ductus arteriosus (DA), an arterial connection in the fetus that directs blood flow away from the pulmonary circulation. A role for prostaglandins in regulating the closure of this vessel has been supported...
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