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Article

Recent insights into the pathogenesis and therapeutics of pulmonary hypertension.

Clinical science (London, England : 1979) - 1 Mar 2002

Strange Julian W, Wharton John, Phillips Peter G, Wilkins Martin R

Abstract excerpt

The normal adult pulmonary circulation is a low-pressure, high-capacity circuit. Pulmonary vascular resistance is regulated by alveolar oxygen tension, potassium channels and a variety of locally produced and circulating vasoactive factors. Perturbations of these systems may contribute to the pathogenesis of pulmonary hypertension. Recently, mutations in BMPR2 and ALK-1, genes that encode members of the...

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Topics

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Share to Bone Morphogenetic Protein Receptors, Type II
Share to Hypertension, Pulmonary

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hypoxia

Share to Potassium Channels

Share to Pulmonary Artery

Share to Pulmonary Disease, Chronic Obstructive

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Source

Identifiers

PMID: 11869166

Genes

ALK
BMPR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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