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Article

The carboxy-terminal domain of ROS1 is essential for 5-methylcytosine DNA glycosylase activity.

Journal of molecular biology - 11 Nov 2014

Hong Samuel, Hashimoto Hideharu, Kow Yoke Wah, Zhang Xing, Cheng Xiaodong

Abstract excerpt

Arabidopsis thaliana repressor of silencing 1 (ROS1) is a multi-domain bifunctional DNA glycosylase/lyase, which excises 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) as well as thymine and 5-hydroxymethyluracil (i.e., the deamination products of 5mC and 5hmC) when paired with a guanine, leaving an apyrimidinic (AP) site that is subsequently incised by the lyase activity. ROS1 is slow in base excision...

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Identifiers

PMID: 25240767
DOI: 10.1016/j.jmb.2014.09.010
PMCID: PMC4253907

Genes

ROS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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