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Article

A discontinuous DNA glycosylase domain in a family of enzymes that excise 5-methylcytosine.

Nucleic acids research - 1 Mar 2011

Ponferrada-Marín María Isabel, Parrilla-Doblas Jara Teresa, Roldán-Arjona Teresa, Ariza Rafael R

Abstract excerpt

DNA cytosine methylation (5-meC) is a widespread epigenetic mark associated to gene silencing. In plants, DEMETER-LIKE (DML) proteins typified by Arabidopsis REPRESSOR OF SILENCING 1 (ROS1) initiate active DNA demethylation by catalyzing 5-meC excision. DML proteins belong to the HhH-GPD superfamily, the largest and most functionally diverse group of DNA glycosylases, but the molecular properties that underlie...

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Identifiers

PMID: 21036872
DOI: 10.1093/nar/gkq982
PMCID: PMC3045615

Genes

ROS1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A discontinuous DNA glycosylase domain in a family of enzymes that excise 5-methylcytosine.PMID 21036872Read ↗

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