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Article

AP endonucleases process 5-methylcytosine excision intermediates during active DNA demethylation in Arabidopsis.

Nucleic acids research - 1 Oct 2014

Lee Jiyoon, Jang Hosung, Shin Hosub, Choi Woo Lee, Mok Young Geun, Huh Jin Hoe

Abstract excerpt

DNA methylation is a primary epigenetic modification regulating gene expression and chromatin structure in many eukaryotes. Plants have a unique DNA demethylation system in that 5-methylcytosine (5mC) is directly removed by DNA demethylases, such as DME/ROS1 family proteins, but little is known about the downstream events. During 5mC excision, DME produces 3'-phosphor-α, β-unsaturated aldehyde and 3'-phosphate by...

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Identifiers

PMID: 25228464
DOI: 10.1093/nar/gku834
PMCID: PMC4191409

Genes

ROS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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