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Article

The DNA repair protein XRCC1 functions in the plant DNA demethylation pathway by stimulating cytosine methylation (5-meC) excision, gap tailoring, and DNA ligation.

The Journal of biological chemistry - 22 Feb 2013

Martínez-Macías María Isabel, Córdoba-Cañero Dolores, Ariza Rafael R, Roldán-Arjona Teresa

Abstract excerpt

DNA methylation patterns are the dynamic outcome of antagonist methylation and demethylation mechanisms, but the latter are still poorly understood. Active DNA demethylation in plants is mediated by a family of DNA glycosylases typified by Arabidopsis ROS1 (repressor of silencing 1). ROS1 and its...

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Share to 5-Methylcytosine
Share to DNA Glycosylases
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Epigenesis, Genetic

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Share to Reactive Oxygen Species

Share to X-ray Repair Cross Complementing Protein 1

Source

Open in PubMed Open full text

Identifiers

PMID: 23316050
DOI: 10.1074/jbc.M112.427617
PMCID: PMC3581409

Genes

ROS1
XRCC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23316050-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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The DNA repair protein XRCC1 functions in the plant DNA demethylation pathway by stimulating cytosine methylation (5-meC) excision, gap tailoring, and DNA ligation.PMID 23316050Read ↗

Preventing transcriptional gene silencing by active DNA demethylation.Semantic proximity Read ↗

The DNA glycosylase/lyase ROS1 functions in pruning DNA methylation patterns in Arabidopsis.Semantic proximity Read ↗

ROS1, a repressor of transcriptional gene silencing in Arabidopsis, encodes a DNA glycosylase/lyase.Semantic proximity Read ↗

The carboxy-terminal domain of ROS1 is essential for 5-methylcytosine DNA glycosylase activity.Semantic proximity Read ↗

A discontinuous DNA glycosylase domain in a family of enzymes that excise 5-methylcytosine.Semantic proximity Read ↗

SIZ1-Mediated SUMOylation of ROS1 Enhances Its Stability and Positively Regulates Active DNA Demethylation in Arabidopsis.Semantic proximity Read ↗

DNA replication factor C1 mediates genomic stability and transcriptional gene silencing in Arabidopsis.Semantic proximity Read ↗

AP endonucleases process 5-methylcytosine excision intermediates during active DNA demethylation in Arabidopsis.Semantic proximity Read ↗

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The cytosolic Fe-S cluster assembly component MET18 is required for the full enzymatic activity of ROS1 in active DNA demethylation.Semantic proximity Read ↗

The chromatin remodeler ERCC6 and the histone chaperone NAP1 are involved in apurinic/apyrimidinic endonuclease-mediated DNA repairSemantic proximity Read ↗

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