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Article

Hu antigen R (HuR) is a positive regulator of the RNA-binding proteins TDP-43 and FUS/TLS: implications for amyotrophic lateral sclerosis.

The Journal of biological chemistry - 14 Nov 2014

Lu Liang, Zheng Lei, Si Ying, Luo Wenyi, Dujardin Gwendal, Kwan Thaddaeus, Potochick Nicholas R, Thompson Sunnie R, Schneider David A, King Peter H

Abstract excerpt

Posttranscriptional gene regulation is governed by a network of RNA-binding proteins (RBPs) that interact with regulatory elements in the mRNA to modulate multiple molecular processes, including splicing, RNA transport, RNA stability, and translation. Mounting evidence indicates that there is a hierarchy within this network whereby certain RBPs cross-regulate other RBPs to coordinate gene expression. HuR, an...

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Identifiers

PMID: 25239623
DOI: 10.1074/jbc.M114.573246
PMCID: PMC4231657

Genes

FUS
SOD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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