Article
Amyotrophic lateral sclerosis-linked mutant SOD1 sequesters Hu antigen R (HuR) and TIA-1-related protein (TIAR): implications for impaired post-transcriptional regulation of vascular endothelial growth factor.
The Journal of biological chemistry - 4 Dec 2009
Lu Liang, Wang Shuying, Zheng Lei, Li Xuelin, Suswam Esther A, Zhang Xiaowen, Wheeler Crystal G, Nabors L B, Filippova Natalia, King Peter H
Abstract excerpt
Down-regulation of vascular endothelial growth factor (VEGF) in the mouse leads to progressive and selective degeneration of motor neurons similar to amyotrophic lateral sclerosis (ALS). In mice expressing ALS-associated mutant superoxide dismutase 1 (SOD1), VEGF mRNA expression in the spinal cord declines significantly prior to the onset of clinical manifestations. In vitro models suggest that dysregulation of...
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