Article
The genetic landscape of gastrointestinal stromal tumor lacking KIT and PDGFRA mutations.
Endocrine - 1 Nov 2014
Boikos Sosipatros A, Stratakis Constantine A
Abstract excerpt
About 10-15 % of adult gastrointestinal stromal tumors (GISTs) and 85 % of pediatric GISTs do not have mutations in the KIT or PDGFRA genes and are generally classified as KIT/PDGFRA wild type (WT). Recent studies have shown that this group of KIT/PDGFRA WT GISTs is quite heterogeneous in terms of clinical phenotype, genetic etiology, and molecular pathways. Succinate dehydrogenase subunit (SDH)-deficient GISTs,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.