Article
Analyses of copy number variation of GK rat reveal new putative type 2 diabetes susceptibility loci.
PloS one - 23 Nov 2010
Ye Zhi-Qiang, Niu Shen, Yu Yang, Yu Hui, Liu Bao-Hong, Li Rong-Xia, Xiao Hua-Sheng, Zeng Rong, Li Yi-Xue, Wu Jia-Rui, Li Yuan-Yuan
Abstract excerpt
Large efforts have been taken to search for genes responsible for type 2 diabetes (T2D), but have resulted in only about 20 in humans due to its complexity and heterogeneity. The GK rat, a spontanous T2D model, offers us a superior opportunity to search for more diabetic genes. Utilizing array comparative genome hybridization (aCGH) technology, we identifed 137 non-redundant copy number variation (CNV) regions...
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