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Article

Methylation-mediated repression of PRDM14 contributes to apoptosis evasion in HPV-positive cancers

18 Sept 2014

Abstract excerpt

Promoter methylation of the transcription factor PRDM14 (PRDI-BF1 and RIZ domain containing 14) represents a highly frequent event in human papillomavirus (HPV)-induced cervical cancers and cancer precursor lesions. Here, we aimed to assess the functional consequences of PRDM14 promoter methylation in HPV-induced carcinogenesis. PRDM14 promoter methylation, expression and consequences of ectopic PRDM14 expression...

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PMID: 25233927
DOI: 10.1093/carcin/bgu197

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