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Article

Repression of MAL tumour suppressor activity by promoter methylation during cervical carcinogenesis

7 Jul 2009

Abstract excerpt

We recently identified MAL (T-lymphocyte maturation associated protein) as the most down-regulated gene in cervical oncogenesis. Here, we examined the mechanism underlying MAL silencing, its functional role in cervical carcinogenesis, and the relevance of detecting MAL alterations for risk assessment of hrHPV-positive women. MAL mRNA expression and promoter methylation were analysed in primary keratinocytes,...

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PMID: 19662663
DOI: 10.1002/path.2598

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