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Epigenetic changes in the <i>CDKN2A</i> locus are associated with differential expression of P16INK4A and P14ARF in HPV‐positive oropharyngeal squamous cell carcinoma

26 Jan 2015

Abstract excerpt

Human papillomavirus (HPV)-positive oropharyngeal squamous cell carcinoma (OPSCC) is recognized as a distinct disease entity associated with improved survival. DNA hypermethylation profiles differ significantly by HPV status suggesting that a specific subset of methylated CpG loci could give mechanistic insight into HPV-driven OPSCC. We analyzed genome-wide DNA methylation of primary tumor samples and adjacent...

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PMID: 25619363
DOI: 10.1002/cam4.374

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