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Article

Genetic variants of NOXA and MCL1 modify the risk of HPV16-associated squamous cell carcinoma of the head and neck.

BMC cancer - 1 May 2012

Zhou Ziyuan, Sturgis Erich M, Liu Zhensheng, Wang Li-E, Wei Qingyi, Li Guojun

Abstract excerpt

BACKGROUND: The cooperation between phorbol 12-myristate 13-acetate induced protein 1 (NOXA) and myeloid cell leukemia 1 (MCL1) is critical in the intrinsic apoptotic pathway. Human papillomavirus 16 (HPV16), by inducing p53 and pRb-E2F degradation, may play an essential role in development of squamous cell carcinoma of the head and neck (SCCHN) through NOXA-MCL1 axis-mediated apoptosis. Therefore, genetic...

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Share to Carcinoma, Squamous Cell
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Human papillomavirus 16

Share to Myeloid Cell Leukemia Sequence 1 Protein

Share to Papillomavirus Infections

Share to Proto-Oncogene Proteins c-bcl-2

Share to Squamous Cell Carcinoma of Head and Neck

Source

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Identifiers

PMID: 22548841
DOI: 10.1186/1471-2407-12-159
PMCID: PMC3428689

Genes

MCL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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