Article
Epigenetic inactivation of TRAIL decoy receptors at 8p12-21.3 commonly deleted region confers sensitivity to Apo2L/trail-Cisplatin combination therapy in cervical cancer.
Genes, chromosomes & cancer - 1 Feb 2016
Narayan Gopeshwar, Xie Dongxu, Ishdorj Ganchimeg, Scotto Luigi, Mansukhani Mahesh, Pothuri Bhavana, Wright Jason D, Kaufmann Andreas M, Schneider Achim, Arias-Pulido Hugo, Murty Vundavalli V
Abstract excerpt
Multiple chromosomal regions are affected by deletions in cervical cancer (CC) genomes, but their consequence and target gene involvement remains unknown. Our single nucleotide polymorphism (SNP) array identified 8p copy number losses localized to an 8.4 Mb minimal deleted region (MDR) in 36% of CC. The 8p MDR was associated with tumor size, treatment outcome, and with multiple HPV infections. Genetic,...
Topics
- Adult
- Aged
- Antineoplastic Combined Chemotherapy Protocols
- Base Sequence
- Cell Line, Tumor
- Cell Survival
- Chromosomes, Human, Pair 8
- Cisplatin
- DNA Methylation