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Article

Methylation‐specific digital karyotyping of HPV16E6E7 ‐expressing human keratinocytes identifies novel methylation events in cervical carcinogenesis

14 May 2013

Abstract excerpt

Transformation of epithelial cells by high-risk human papillomavirus (hrHPV) types can lead to anogenital carcinomas, particularly cervical cancer, and oropharyngeal cancers. This process is associated with DNA methylation alterations, often affecting tumour suppressor gene expression. This study aimed to comprehensively unravel genome-wide DNA methylation events linked to a transforming hrHPV-infection, which is...

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PMID: 23674368
DOI: 10.1002/path.4210

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