Article
An optimized optogenetic clustering tool for probing protein interaction and function.
Nature communications - 18 Sept 2014
Taslimi Amir, Vrana Justin D, Chen Daniel, Borinskaya Sofya, Mayer Bruce J, Kennedy Matthew J, Tucker Chandra L
Abstract excerpt
The Arabidopsis photoreceptor cryptochrome 2 (CRY2) was previously used as an optogenetic module, allowing spatiotemporal control of cellular processes with light. Here we report the development of a new CRY2-derived optogenetic module, 'CRY2olig', which induces rapid, robust, and reversible protein oligomerization in response to light. Using this module, we developed a novel protein interaction assay,...
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