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Article

Membrane curvature sensing by the C-terminal domain of complexin.

Nature communications - 17 Sept 2014

Snead David, Wragg Rachel T, Dittman Jeremy S, Eliezer David

Abstract excerpt

Complexin functions at presynaptic nerve terminals to inhibit spontaneous SNARE-mediated synaptic vesicle (SV) exocytosis, while enhancing stimulated neurotransmitter release. The C-terminal domain (CTD) of complexin is essential for its inhibitory function and has been implicated in localizing complexin to SVs via direct membrane interactions. Here we show that complexin's CTD is highly sensitive to membrane...

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Share to Adaptor Proteins, Vesicular Transport
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25229806
DOI: 10.1038/ncomms5955
PMCID: PMC4180495

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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