Article
Frequency assessment of BRAF mutation, KRas mutation, and RASSF1A methylation in nodular goitre based on fine-needle aspiration cytology specimens Ocena częstości występowania mutacji genów BRAF, KRas oraz.
Endokrynologia Polska - 1 Jan 2015
Koziołek Monika, Bińczak-Kuleta Agnieszka, Stepaniuk Maria, Parczewski Miłosz, Andrysiak-Mamos Elżbieta, Sieradzka Anna, Safranow Krzysztof, Osowicz-Korolonek Lilianna, Kiedrowicz Bartosz, Kram Andrzej, Ciechanowicz Andrzej, Syrenicz Anhelli
Abstract excerpt
INTRODUCTION: Standard pre-operative diagnosis of nodular goitre is not always conclusive. The decision about nodular goitre surgery is increasingly based on molecular methods. The aim of the study was to determine BRAF T1799A mutation and KRas proto-oncogene mutation, and the analysis of RASSF1A promoter methylation level in cytological material obtained from FNAB specimens of thyroid nodules. MATERIAL AND...
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