Article
Normal B-1a cell development requires B cell-intrinsic NFATc1 activity.
Proceedings of the National Academy of Sciences of the United States of America - 11 Nov 2003
Berland Robert, Wortis Henry H
Abstract excerpt
B-1a cells, an anatomically, phenotypically, and functionally distinct subset of B cells that produce the bulk of natural serum IgM and much of gut-associated IgA, are an important component of the early response to pathogens. Because the induced expression of CD5, a hallmark of B-1a cells, requires a nuclear factor of activated T cells (NFAT)-dependent enhancer, we examined the role of NFAT transcription factors...
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