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Different genetic profiles contribute to worse overall survival in patients with leptomeningeal metastases of non-small-cell lung cancer.

Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico - 1 Dec 2024

Tang Xusheng, Hu Xiaojuan, Yuan Lin, Yang Hainan, Luo Yunfen, Liu Da, Hu Qingjun, Shan Changguo, Lin Tao, Cai Linbo, Zhou Zhaoming, Jin Xin, Lei Ming, Hong Weiping

Abstract excerpt

BACKGROUND: To assess the genetic characteristics of central nervous system (CNS) metastases from non-small-cell lung cancer (NSCLC), we gathered the genetic profiles of brain metastases (BM) and leptomeningeal metastases (LM). Our objective was to identify genetic factors contributing to poorer overall survival (OS) in NSCLC patients with LM. METHODS: This study included 25 consecutive patients with BM and 52...

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Identifiers

PMID: 38795257
DOI: 10.1007/s12094-024-03507-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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