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Article

Transcription coactivator mediator subunit MED1 Is required for the development of fatty liver in the mouse

12 Jan 2011

Abstract excerpt

UNLABELLED: Peroxisome proliferator-activated receptor-γ (PPARγ), a nuclear receptor, when overexpressed in liver stimulates the induction of adipocyte-specific and lipogenesis-related genes and causes hepatic steatosis. We report here that Mediator 1 (MED1; also known as PBP or TRAP220), a key subunit of the Mediator complex, is required for high-fat diet-induced hepatic steatosis as well as PPARγ-stimulated...

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Share to Adipokines, Inflammation, and Metabolic Diseases
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PMID: 21480322
DOI: 10.1002/hep.24155

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